CT1341: some effects in man.

CT1341: interaction with some anaesthetic agents.

The interaction of the steroid anaesthetic agent CT1341 with selected muscle relaxants and volatile agents has been investigated in man. In four patients the effect at the neuromuscular junction was examined. No effect was seen with CT1341 alone and there was no clinically significant interaction with tubocurarine, pancuronium or suxamethonium. A further forty patients in six groups were anaest...

Some circulatory effects of 5-hydroxytryptamine in man.

Some neurophysiological effects of cerebellar stimulation in man.

This paper presents the results of neurophysiological studies of the effects of cerebellar stimulation on H reflexes, late reflexes, blink reflexes, evoked potentials and EEG patterns in 18 human subjects (Male 13, Female 5, Age 25.8+/-10.0, Epileptic 9, Cerebral Palsy 9). In addition to the effects of cerebellar stimulation on the H reflex studies on soleus we assessed V1 and V2, "late" respon...

Some functional effects of sectioning the cerebral commissures in man.

Some of these studies have been reported in a preliminary communication, Hoffee, P., and E. Englesberg, Bacteriol. Proc., 1962, p. 120. Abbreviations: ATP, adenosine triphosphate; aMG, alpha methyl D-glucopyranoside. t Predoctoral Research Fellow, U.S. Public Health Service. l Rickenberg, H. V., G. N. Cohen, G. Buttin, and J. Monod, Ann. Inst. Pasteur, 91, 829 (1956). 2 Cohen, G. N., and J. Mon...

Some metabolic effects of sodium nitroprusside in man.

The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B(12) tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions t...